Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL-derived mRNA transcripts that can substitute for IL3 signaling. We demonstrate that CRLF2 is overexpressed in approximately 15% of adult and high-risk pediatric B-AL...
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1Division of Pediatric Hematology-Oncology and 2Department of Pediatrics, University of California, San Francisco, San Francisco, CA; 3Department of Pathology, Johns Hopkins University, Baltimore, MD; 4Department of Laboratory Medicine, University of Washington, Seattle, WA; 5Department of Pathology and University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM; 6Departme...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0911726107